Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

Covering: up to mid-2015 Recently identified natural atropisomeric compounds with
potential medicinal applications are presented. The ability of natural receptors to possess …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

FtsZ, a bacterial homolog of tubulin, is well established as forming the cytoskeletal
framework for the cytokinetic ring. Recent work has shown that purified FtsZ, in the absence …

Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although
far more than one million are expected. The variety of species and the diversity of their …

Bacterial infection remains a serious threat to human lives because of emerging resistance
to existing antibiotics. Although the scientific community has avidly pursued the discovery of …

The assembly and stability of FtsZ protofilaments have been shown to play critical roles in
bacterial cytokinesis. Recent evidence suggests that FtsZ may be considered as an …

Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …