Deubiquitylases from genes to organism
Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …
cell physiology. It is reversed through the action of a large family of deubiquitylating …
AMPK signaling and its targeting in cancer progression and treatment
The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …
Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship
RN Wang, L Rosenberg - Journal of Endocrinology, 1999 - joe.bioscientifica.com
Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …
that promote energy expenditure can be utilized for effective therapy. Src-associated in …
Functional analysis of deubiquitylating enzymes in tumorigenesis and development
Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …
Comparative proteomics to reveal muscle-specific beef color stability of Holstein cattle during post-mortem storage
Label-free strategy was applied to elucidate muscle-specific beef (M. longissimuss
lumborum (LL) and M. psoas major (PM)) color stability of Holstein cattle during post-mortem …
lumborum (LL) and M. psoas major (PM)) color stability of Holstein cattle during post-mortem …
Changes to PUFA-PPAR pathway during mesaconitine induced myocardial coagulative necrosis
Q Chen, X Deng, K Zhang, Y Kang, M Jiao… - Food and Chemical …, 2023 - Elsevier
Coagulation necrosis is characterized by the denaturation of structural proteins and
lysosomal enzymes; its occurrence in myocardium can lead to heart failure. Current studies …
lysosomal enzymes; its occurrence in myocardium can lead to heart failure. Current studies …
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice
ES Coyne, N Bédard, YJ Gong, M Faraj, A Tchernof… - Diabetologia, 2019 - Springer
Aims/hypothesis Elucidating the molecular mechanisms of fat accumulation and its
metabolic consequences is crucial to understanding and treating obesity, an epidemic …
metabolic consequences is crucial to understanding and treating obesity, an epidemic …
Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model
Background Obesity is associated with various progressive age-related diseases, including
neurological disorders. However, underlying molecular basis for increased risk of …
neurological disorders. However, underlying molecular basis for increased risk of …
Ubiquitin carboxyl-terminal hydrolases and human malignancies: the novel prognostic and therapeutic implications for head and neck cancer
C Rong, R Zhou, S Wan, D Su, SL Wang… - Frontiers in oncology, 2021 - frontiersin.org
Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs),
have been found in a variety of tumor entities and play distinct roles in the pathogenesis and …
have been found in a variety of tumor entities and play distinct roles in the pathogenesis and …
A new map to understand deubiquitination
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The
importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes …
importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes …