Allostery: an overview of its history, concepts, methods, and applications
J Liu, R Nussinov - PLoS computational biology, 2016 - journals.plos.org
The concept of allostery has evolved in the past century. In this Editorial, we briefly overview
the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect …
the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect …
Integrated computational approaches and tools for allosteric drug discovery
O Sheik Amamuddy, W Veldman, C Manyumwa… - International journal of …, 2020 - mdpi.com
Understanding molecular mechanisms underlying the complexity of allosteric regulation in
proteins has attracted considerable attention in drug discovery due to the benefits and …
proteins has attracted considerable attention in drug discovery due to the benefits and …
Allosteric modulator discovery: from serendipity to structure-based design
Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …
pharmacological advantages than orthosteric ligands. The discovery of allosteric …
The role of dimer asymmetry and protomer dynamics in enzyme catalysis
INTRODUCTION Enzymes greatly accelerate biochemical reactions by providing a scaffold
to bind and recognize substrate, position catalytic units, and facilitate the formation of …
to bind and recognize substrate, position catalytic units, and facilitate the formation of …
Exploring and learning the universe of protein allostery using artificial intelligence augmented biophysical and computational approaches
Allosteric mechanisms are commonly employed regulatory tools used by proteins to
orchestrate complex biochemical processes and control communications in cells. The …
orchestrate complex biochemical processes and control communications in cells. The …
[HTML][HTML] Protein dynamics underlying allosteric regulation
Allostery is the mechanism by which information and control are propagated in
biomolecules. It regulates ligand binding, chemical reactions, and conformational changes …
biomolecules. It regulates ligand binding, chemical reactions, and conformational changes …
[HTML][HTML] NMR tools to detect protein allostery
Allostery is a fundamental mechanism of cellular homeostasis by intra-protein
communication between distinct functional sites. It is an internal process of proteins to steer …
communication between distinct functional sites. It is an internal process of proteins to steer …
Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9
CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat and associated
Cas9 protein) is a molecular tool with transformative genome editing capabilities. At the …
Cas9 protein) is a molecular tool with transformative genome editing capabilities. At the …
[HTML][HTML] Biomolecular NMR spectroscopy in the era of artificial intelligence
Biomolecular nuclear magnetic resonance (NMR) spectroscopy and artificial intelligence
(AI) have a burgeoning synergy. Deep learning-based structural predictors have forever …
(AI) have a burgeoning synergy. Deep learning-based structural predictors have forever …
On the perturbation nature of allostery: sites, mutations, and signal modulation
E Guarnera, IN Berezovsky - Current opinion in structural biology, 2019 - Elsevier
Regardless of the diversity of systems, allosteic signalling is found to be always caused by
perturbations. This recurring trait of allostery serves as a foundation for developing different …
perturbations. This recurring trait of allostery serves as a foundation for developing different …