Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of developing cardiovascular …

The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is
dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through …

In this article we present validation of a real-time RT–PCR method to quantitate mRNA
expression levels of atrial natriuretic peptide and c-fos in anin vitromodel of cardiac …

Reperfusion is a pre-requisite to salvaging viable myocardium, following an acute
myocardial infarction. Reperfusion of ischaemic myocardium, however, is not without risk, as …

Members of the mitogen‐activated protein kinase (MAPK) cascade such as extracellular
signal‐regulated kinase (ERK), c‐Jun N‐terminal kinase (JNK) and p38 are implicated as …

Heart failure is a leading cause of mortality in the United States. As a result of advances in
genetic technology, a molecular basis of heart failure is emerging. 1, 2 This review highlights …

Background—IGF-1 has been shown to protect myocardium against death in animal models
of infarct and ischemia-reperfusion injury. In the present study, we investigated the role of …

Background—Myocardial sympathetic activity is increased in heart failure. We tested the
hypothesis that norepinephrine (NE) stimulates apoptosis in adult rat ventricular myocytes in …

Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …