Clusterin in Alzheimer's disease: mechanisms, genetics, and lessons from other pathologies
EM Foster, A Dangla-Valls, S Lovestone… - Frontiers in …, 2019 - frontiersin.org
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
Epigenetic signaling and crosstalk in regulation of gene expression and disease progression
S Manna, J Mishra, T Baral, R Kirtana, P Nandi… - …, 2023 - Taylor & Francis
Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …
Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death
The physico-chemical properties of nanoparticle (NP), such as particle size, surface defects,
crystallinity and accessible surface, affect NP photocatalytic activity that in turn defines the …
crystallinity and accessible surface, affect NP photocatalytic activity that in turn defines the …
Overexpression of SOX2 gene by histone modifications: SOX2 enhances human prostate and breast cancer progression by prevention of apoptosis and enhancing …
SKNAR SamirKumarPatra - Oncology, 2023 - karger.com
Introduction: SOX2 plays a crucial role in tumor development, cancer stem cell maintenance,
and cancer progression. Mechanisms of SOX2 gene regulation in human breast and …
and cancer progression. Mechanisms of SOX2 gene regulation in human breast and …
Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy
Clusterin (CLU) is an evolutionary conserved molecular chaperone present in different
human tissues and fluids and established to be a significant cancer regulator. It controls …
human tissues and fluids and established to be a significant cancer regulator. It controls …
How Can the Microbiome Induce Carcinogenesis and Modulate Drug Resistance in Cancer Therapy?
I Mendes, N Vale - International Journal of Molecular Sciences, 2023 - mdpi.com
Over the years, cancer has been affecting the lives of many people globally and it has
become one of the most studied diseases. Despite the efforts to understand the cell …
become one of the most studied diseases. Despite the efforts to understand the cell …
[HTML][HTML] Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of …
Loss of E-cadherin and epithelial to mesenchymal transition (EMT) are key steps in cancer
progression. Reactive oxygen species (ROS) play significant roles in cellular physiology and …
progression. Reactive oxygen species (ROS) play significant roles in cellular physiology and …
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been
key challenges to effective treatment for patients. It has been suggested that a subpopulation …
key challenges to effective treatment for patients. It has been suggested that a subpopulation …
Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
Aims Secretory clusterin (sCLU) plays an important role in tumor development and cancer
progression. However, the molecular mechanisms and physiological functions of sCLU in …
progression. However, the molecular mechanisms and physiological functions of sCLU in …