Seeing (and using) the light: recent developments in bioluminescence technology

AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

Optogenetics and its application in neural degeneration and regeneration

JD Ordaz, W Wu, XM Xu - Neural regeneration research, 2017 - journals.lww.com
Neural degeneration and regeneration are important topics in neurological diseases. There
are limited options for therapeutic interventions in neurological diseases that provide …

Compressive imaging through a multimode fiber

LV Amitonova, JF De Boer - Optics letters, 2018 - opg.optica.org
We propose and experimentally demonstrate a new concept of endo-microscopy:
compressive multimode (MM) fiber imaging. We show that the speckle patterns generated in …

[HTML][HTML] In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

IV Kelmanson, AG Shokhina, DA Kotova… - Redox Biology, 2021 - Elsevier
Ischemic cerebral stroke is one of the leading causes of death and disability in humans.
However, molecular processes underlying the development of this pathology remain poorly …

Imaging and optogenetic modulation of vascular mural cells in the live brain

L Tong, RA Hill, EC Damisah, KN Murray, P Yuan… - Nature protocols, 2021 - nature.com
Mural cells (smooth muscle cells and pericytes) are integral components of brain blood
vessels that play important roles in vascular formation, blood–brain barrier maintenance …

Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice

F Schlegel, Y Sych, A Schroeter, J Stobart, B Weber… - Nature protocols, 2018 - nature.com
Despite the growing popularity of blood oxygen level–dependent (BOLD) functional MRI
(fMRI), understanding of its underlying principles is still limited. This protocol describes a …

[HTML][HTML] The fiber-optic imaging and manipulation of neural activity during animal behavior

D Miyamoto, M Murayama - Neuroscience research, 2016 - Elsevier
Recent progress with optogenetic probes for imaging and manipulating neural activity has
further increased the relevance of fiber-optic systems for neural circuitry research. Optical …

Let there be light—optoprobes for neural implants

MT Alt, E Fiedler, L Rudmann, JS Ordonez… - Proceedings of the …, 2016 - ieeexplore.ieee.org
Over the past decades, optical technologies have entered neural implant technologies.
Applications such as optogenetics, near-infrared spectroscopy (NIRS), and direct-near …

Rotational memory effect of a multimode fiber

LV Amitonova, AP Mosk, PWH Pinkse - Optics express, 2015 - opg.optica.org
We demonstrate the rotational memory effect in a multimode fiber. Rotating the incident
wavefront around the fiber core axis leads to a rotation of the resulting pattern of the fiber …

Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

X Chen, F Sobczak, Y Chen, Y Jiang, C Qian… - Nature …, 2019 - nature.com
Extensive in vivo imaging studies investigate the hippocampal neural network function,
mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI …