Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2
phases of the cell cycle,–. Several HR proteins are preferentially recruited to DSBs at …

Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …

R-loop structures act as modulators of physiological processes such as transcription
termination, gene regulation, and DNA repair. However, they can cause transcription …

MicroRNAs (miRNAs) play vital roles in the regulation of gene expression, a process known
as miRNA-induced gene silencing. The human genome codes for many miRNAs, and their …

While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR)
is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are …