Cisplatin binding to proteins: A structural perspective
The interactions of clinically established anticancer Pt-based drugs with proteins play crucial
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …
Pt-based drugs: the spotlight will be on proteins
O Pinato, C Musetti, C Sissi - Metallomics, 2014 - academic.oup.com
Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
A Potent Trans‐Diimine Platinum Anticancer Complex Photoactivated by Visible Light
A Potent Trans‐Diimine Platinum Anticancer Complex Photoactivated by Visible Light × Close
The Infona portal uses cookies, ie strings of text saved by a browser on the user's device. The …
The Infona portal uses cookies, ie strings of text saved by a browser on the user's device. The …
N-heterocyclic carbene-amine Pt (II) complexes, a new chemical space for the development of platinum-based anticancer drugs
M Skander, P Retailleau, B Bourrié… - Journal of medicinal …, 2010 - ACS Publications
N-Heterocyclic carbene (NHC) platinum complexes have been highlighted as a promising
and original platform for building new cytotoxic drugs of the cisplatin series. Mixed NHC …
and original platform for building new cytotoxic drugs of the cisplatin series. Mixed NHC …
Gold nanorods for platinum based prodrug delivery
Gold nanorods for platinum based prodrug delivery - Chemical Communications (RSC
Publishing) DOI:10.1039/C0CC03108A Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C0CC03108A Royal Society of Chemistry View PDF VersionPrevious …
Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA
AG Quiroga - Journal of inorganic Biochemistry, 2012 - Elsevier
This focused review is devoted to our advances in developing trans platinum complexes as
antitumoral complexes, in particular those bearing aliphatic amines. It includes some …
antitumoral complexes, in particular those bearing aliphatic amines. It includes some …
Identification of [PtCl2(phen)] Binding Modes in Amyloid‐β Peptide and the Mechanism of Aggregation Inhibition
Platinum phenanthroline complexes inhibit amyloid‐β (Aβ) aggregation and reduce Aβ‐
caused neurotoxicity [Proc. Natl. Acad. Sci., 2008, 105, 6813–6818]. In this study, we …
caused neurotoxicity [Proc. Natl. Acad. Sci., 2008, 105, 6813–6818]. In this study, we …
Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts
Oxaliplatin and carboplatin are two platinum (II) drugs in widespread clinical use for the
treatment of various types of cancers; yet, structural information on their interactions with …
treatment of various types of cancers; yet, structural information on their interactions with …
Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria
L Zhang, Y Zheng, B Callahan, M Belfort… - Journal of Biological …, 2011 - ASBMB
Mycobacterium tuberculosis harbors three protein splicing elements, called inteins, in critical
genes and their protein products. Post-translational removal of the inteins occurs …
genes and their protein products. Post-translational removal of the inteins occurs …
Optimizing the electronic properties of photoactive anticancer oxypyridine-bridged dirhodium (II, II) complexes
Z Li, A David, BA Albani, JP Pellois… - Journal of the …, 2014 - ACS Publications
A series of partial paddlewheel dirhodium compounds of general formula cis-[Rh2 (xhp) 2
(CH3CN) n][BF4] 2 (n= 5 or 6) were synthesized {xhp= 6-R-2-oxypyridine ligands, R=− CH3 …
(CH3CN) n][BF4] 2 (n= 5 or 6) were synthesized {xhp= 6-R-2-oxypyridine ligands, R=− CH3 …