Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …
designed to recapitulate the important biological and physiological parameters of their in …
A microfluidically perfused three dimensional human liver model
K Rennert, S Steinborn, M Gröger, B Ungerböck… - Biomaterials, 2015 - Elsevier
Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of
hepatocyte polarization and maintenance of metabolic function. We here report the …
hepatocyte polarization and maintenance of metabolic function. We here report the …
Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies
The liver performs many key functions, the most prominent of which is serving as the
metabolic hub of the body. For this reason, the liver is the focal point of many investigations …
metabolic hub of the body. For this reason, the liver is the focal point of many investigations …
Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response
The liver is a central organ in the human body and first line of defense between host and
external environment. Liver response to any external perturbation is a collective reaction of …
external environment. Liver response to any external perturbation is a collective reaction of …
Opportunities and considerations for studying liver disease with microphysiological systems on a chip
Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …
Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions
In vitro liver models provide essential information for evaluating drug metabolism, metabolite
formation, and hepatotoxicity. Interfacing liver models with other organ models could provide …
formation, and hepatotoxicity. Interfacing liver models with other organ models could provide …
Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems
DJ Hughes, T Kostrzewski… - … Biology and Medicine, 2017 - journals.sagepub.com
Liver disease represents a growing global health burden. The development of in vitro liver
models which allow the study of disease and the prediction of metabolism and drug-induced …
models which allow the study of disease and the prediction of metabolism and drug-induced …
A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions
SS Bale, A Manoppo, R Thompson… - Biotechnology and …, 2019 - Wiley Online Library
Hepatic in vitro platforms ranging from multi‐well cultures to bioreactors and microscale
systems have been developed as tools to recapitulate cellular function and responses to aid …
systems have been developed as tools to recapitulate cellular function and responses to aid …
New technologies in drug metabolism and toxicity screening: organ-to-organ interaction
Pharmaceutical drugs are necessary to cure or slow down the progression of diseases. The
promising chemical and biological candidates that go through the drug development …
promising chemical and biological candidates that go through the drug development …