Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …

Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …

Mitochondrial and autophagic dysfunction as well as neuroinflammation are involved in the
pathophysiology of Parkinson's disease (PD). We hypothesized that targeting the …

Cancer is the second cause of death worldwide, exceeded only by cardiovascular diseases.
The prevalent treatment currently used against metastatic cancer is chemotherapy. Among …

A novel family of 2Fe–2S proteins, the NEET family, was discovered during the last decade
in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an …

Adipose tissue in the body is classified as white adipose tissue (WAT); a fat-accumulating
tissue, or brown adipose tissue (BAT); an energy-dissipating tissue. Transforming WAT-to …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with its associated
morbidity and mortality. Many pathophysiological pathways such as oxidative stress …

Highlights•Mitochondrial dysfunction plays an important part in several diseases.•mitoNEET
is a mitochondrial protein that regulates bioenergetics in cells.•mitoNEET ligands to date are …

Several molecular pathways are currently being targeted in attempts to develop disease-
modifying therapies to slow down neurodegeneration in Parkinson's disease. Failure of …