The hepatic mitochondrial pyruvate carrier as a regulator of systemic metabolism and a therapeutic target for treating metabolic disease
KS McCommis, BN Finck - Biomolecules, 2023 - mdpi.com
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product
of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy …
of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy …
UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier
L Ran, M Chen, J Ye, S Zhang, Z Luo, T Bai… - Advanced …, 2024 - Wiley Online Library
Targeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy
for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of …
for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of …
[HTML][HTML] Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: in vivo mechanism revealed by metabolomics (liquid …
J Chen, C Ye, Z Yang, C Zhang, P Li, B Xu, A Wu… - Phytomedicine, 2023 - Elsevier
Objective Erchen decoction, a traditional Chinese medicine formula, can reduce the level of
oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome …
oxidative stress for the treatment of dyslipidemia phlegm-dampness retention syndrome …
Inhibition of pyruvate dehydrogenase kinase 4 attenuates myocardial and mitochondrial injury in sepsis-induced cardiomyopathy
T Chen, L Ye, J Zhu, B Tan, Q Yi, Y Sun… - The Journal of …, 2024 - academic.oup.com
Background Sepsis-induced cardiomyopathy (SIC) is a cardiac dysfunction caused by
sepsis, with mitochondrial dysfunction being a critical contributor. Pyruvate dehydrogenase …
sepsis, with mitochondrial dysfunction being a critical contributor. Pyruvate dehydrogenase …
Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors
Y Huang, H Zhang, X Peng, Q Zhang - Pharmaceutical Fronts, 2024 - thieme-connect.com
The mitochondrial pyruvate carrier (MPC) exists in the mitochondria inner membrane which
transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the …
transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the …
Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson's disease
X Zhang, L Zhou, Y Peng, S He, Z Mao, J Cai… - Biochemical …, 2024 - Elsevier
Copper serves as an indispensable cofactor for all living organisms, and its excessive
accumulation has been associated with a variety of diseases. Wilson's disease (WD) serves …
accumulation has been associated with a variety of diseases. Wilson's disease (WD) serves …
Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex
CM Hadfield, JK Walker, C Arnatt, KS McCommis - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The mitochondrial pyruvate carrier (MPC) plays a role in numerous diseases including
neurodegeneration, metabolically dependent cancers, and the development of insulin …
neurodegeneration, metabolically dependent cancers, and the development of insulin …