Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Positron emission tomography (PET) is a powerful analytical tool for in vivo molecular
imaging of the human brain. Over the past years, a number of PET studies imaging the …

Intermittent fasting may be an effective intervention to protect against age-related metabolic
disturbances, although it is still controversial. Here, we investigated the effect of intermittent …

Alzheimer's disease (AD) is a progressive and ultimately fatal neurodegenerative diseases.
Aluminum, a neurotoxic metal, is considered as the pathological hallmark and contributing …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

Accumulation of α-synuclein (α-syn) is a neuropathological hallmark of synucleinopathies.
To date, no selective α-syn positron emission tomography (PET) radiotracer has been …

Background Many trials of amyloid‐modulating agents fail to improve cognitive outcome in
Alzheimer's disease despite substantial reduction of amyloid β levels. Methods We applied a …

Background Despite a tremendous amount of information on the role of amyloid in
Alzheimer's disease (AD), almost all clinical trials testing this hypothesis have failed to …

There is increasing evidence that the serotonergic system is highly dysfunctional in
Alzheimer's disease (AD), and this could be related to cognitive impairments associated with …

PET imaging studies using 5-HT 1A receptor radiotracers show a decreased density of this
receptor in hippocampi of patients with Alzheimer's disease (AD) at advanced stages …