The loss of functional response upon continuous or repeated exposure to agonist,
desensitization, is an intriguing phenomenon if not as yet a well‐defined physiological …

Inflammatory responses to stimuli are essential body defenses against foreign threats.
However, uncontrolled inflammation may result in serious health problems, which can be life …

Highly correlated neural activity in the form of spontaneous waves of action potentials is
present in the developing retina weeks before vision. Optical imaging revealed that these …

Lorna W. Role* and Darwin K. Berg† Heinemann et al., 1990a; Sargent, 1993; Patrick et al.,*
Department of Cell Biology and Anatomy 1993). Eight are designated as α-type (α2–α9) and …

The α7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly
expressed in hippocampus and is implicated in modulating neurotransmitter release and in …

Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …

Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative,
behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine …

Alzheimer's disease produces a devastating decline in mental function, with profound effects
on learning and memory. Early consequences of the disease include the specific loss of …

The human α7 neuronal nicotinic acetylcholine receptor gene (HGMW-approved symbol
CHRNA7) has been characterized from genomic clones. The gene is similar in structure to …

▪ Abstract Activation of different types of G-protein-linked and ionotropic presynaptic
receptors has been shown to regulate neurotransmitter release throughout the central and …