Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

X Liu, H Yang, Z Liu - International Immunopharmacology, 2022 - Elsevier
Paraquat poisoning is a severe health problem globally, particularly in developing countries.
Due to its severe toxicity, the mortality rate of paraquat poisoning is greatly higher than other …

Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis

B Wei, C Sun, H Wan, Q Shou, B Han, M Sheng… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Salvia miltiorrhiza Bunge (SM) is an outstanding
herbal medicine with various traditional effects, especially promoting blood circulation to …

Co-assembled supramolecular hydrogel of salvianolic acid b and a phosphopeptide for enhanced wound healing

X Huang, T Li, X Jiang, Z Wang, M Wang… - … Applied Materials & …, 2023 - ACS Publications
Supramolecular natural product gels (NPGs) have emerged as promising biomaterials for
scalable and adjustable drug delivery systems. These gels possess biocompatibility …

Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2-and SIRT1-dependent pathways

X Zhang, Q Wu, Y Lu, J Wan, H Dai, X Zhou… - Free Radical Biology …, 2018 - Elsevier
Salvianolic acid B (SalB), a natural polyphenolic compound extracted from the herb of Salvia
miltiorrhiza, possesses antioxidant and neuroprotective properties and has been shown to …

Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

Y Pang, PC Zhang, RR Lu, HL Li, J Li, HX Fu… - Frontiers in …, 2020 - frontiersin.org
Acute kidney injury (AKI) is a serious disease characterized by a rapid decline in kidney
function. Oxidative stress is the primary pathogenesis of AKI. Salvianolic acid B (SalB), a …

Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats

H Lv, L Wang, J Shen, S Hao, A Ming, X Wang… - Brain Research …, 2015 - Elsevier
Abstract Silent information regulator 1 (SIRT1), a histone deacetylase, has been suggested
to be effective in ischemic brain diseases. Salvianolic acid B (SalB) is a polyphenolic and …

SIRT1 protects against oxidative stress‐induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation

YQ Wang, Q Cao, F Wang, LY Huang… - Journal of cellular …, 2015 - Wiley Online Library
Cell loss due to apoptosis induced by oxidative stress is a major hurdle for endothelial
progenitor cells (EPCs)‐based therapy. Sirtuin 1 (SIRT1) plays important roles in many …

PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model

S Lin, L Cui, G Chen, J Huang, Y Yang, K Zou, Y Lai… - Biomaterials, 2019 - Elsevier
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized
spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we …

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death

H Lv, Q Liu, J Zhou, G Tan, X Deng, X Ci - Free Radical Biology and …, 2017 - Elsevier
Daphnetin (Daph), a natural coumarin derivative isolated from plants of the Genus Daphne,
possesses abundant biological activities, such as anti-inflammatory, antioxidant and …

Icariin promotes angiogenic differentiation and prevents oxidative stress‐induced autophagy in endothelial progenitor cells

Y Tang, A Jacobi, C Vater, L Zou, X Zou, M Stiehler - Stem cells, 2015 - academic.oup.com
Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of
endothelium are frequently observed in patients with diabetes and cardiovascular disease …