Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …

Despite significant improvements in therapy, the HIV/AIDS pandemic remains an important
threat to public health. Current treatments fail to eradicate HIV as proviral DNA persists in …

Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …

A better understanding of HIV-1 latency is a research priority in HIV cure research.
Conversely, little is known about the latency characteristics of HIV-2, the closely related …

HIV-1 integrates more frequently into transcribed genes, however the biological significance
of HIV-1 integration targeting has remained elusive. Using a selective high-throughput …

A permanent cure remains the greatest challenge in the field of HIV research. In order to
reach this goal, a profound understanding of the molecular mechanisms controlling HIV …

To complete their replication cycle, retroviruses need to integrate a DNA copy of their RNA
genome into a host chromosome. Integration site selection is not random and is driven by …

Chromosomal fragile sites (FSs) are loci where gaps and breaks may occur and are
preferential integration targets for some viruses, for example, Hepatitis B, Epstein‐Barr virus …

Human immunodeficiency virus type 2 (HIV-2) accumulates fewer mutations during
replication than HIV type 1 (HIV-1). Advanced studies of HIV-2 mutagenesis, however, have …

[25–30]. Moreover, the treatment is not very specific and therefore results in an overall
activation and clear toxicity. Gene editing has been pursued as an alternative approach …