For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water
and molecular oxygen. The catalase gene has all the characteristics of a housekeeping …

Cancer is typically a consequence of imbalance between cell death and proliferation in a
way favorable to cell proliferation and survival. Most conventional cancer therapies are …

Ovarian cancer (OC) is one of the deadliest cancers among women contributing to high risk
of mortality, mainly owing to delayed detection. There is no specific biomarker for its …

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression
has been widely demonstrated to occur in various types of cancer. Overexpression of …

Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction
of cell death. Dysregulated expression of IAPs is frequently observed in cancers, and the …

Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis
pathways are especially critical as they confer resistance to conventional anti-cancer …

YM155, a novel survivin suppressant, shows potent antitumor activity against various human
cancers and is currently in phase II clinical trials. In this study, we investigated whether …

Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …