Hot-melt extrusion: from theory to application in pharmaceutical formulation—where are we now?

H Patil, SK Vemula, S Narala, P Lakkala… - AAPS …, 2024 - Springer
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …

Pharmacy 3D printing

J Cheng, E Tan, L Kang - Biofabrication, 2024 - iopscience.iop.org
A significant limitation of the “one size fits all” medication approach is the lack of
consideration for special population groups. 3D printing technology has revolutionised the …

Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed tablets with an immediate release of a BCS II molecule

O Jennotte, N Koch, A Lechanteur, F Rosoux… - International Journal of …, 2023 - Elsevier
Among the various 3D printing techniques, FDM is the most studied in pharmaceutical
research. However, it requires the fabrication of filaments with suitable mechanical …

Multilevel categoric factorial design for optimization of raloxifene hydrochloride solid dispersion in PVP K30 by hot-melt extrusion technology

RM Elkanayati, S Omari, AAA Youssef… - Journal of Drug Delivery …, 2024 - Elsevier
Raloxifene Hydrochloride (RLH) is a selective estrogen receptor modulator (SERM) used for
the treatment and prevention of postmenopausal osteoporosis. This Active Pharmaceutical …

Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle fused deposition modeling 3D printing

P Zhang, J Li, EA Ashour, S Chung, H Wang… - International Journal of …, 2024 - Elsevier
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused
deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt …

Single-Step Extrusion Process for Formulation Development of Self-Emulsifying Granules for Oral Delivery of a BCS Class IV Drug

VR Kulkarni, S Bashyal, VV Nair, I Duggal… - Molecular …, 2024 - ACS Publications
This study aimed to develop and optimize formulations containinga BCS Class IV drug by
improving its solubility and permeability. Herein development of self-emulsifying solid lipid …

3D printing in vaginal drug delivery: a revolution in pharmaceutical manufacturing

S Narala, AA Ali Youssef, SR Munnangi… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction The Food and Drug Administration's approval of the first three-
dimensional (3D) printed tablet, Spritam®, led to a burgeoning interest in using 3D printing …

Fabrication of osmotic pump tablets utilizing semisolid extrusion three-dimensional printing technology

H Chen, D Fang, X Wang, Y Gong, Y Ji… - International Journal of …, 2024 - Elsevier
The utilization of three-dimensional (3D) printing technology is prevalent in the fabrication of
oral sustained release preparations; however, there is a lack of research on 3D-printed …

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

Á Aguilar-de-Leyva, M Casas, C Ferrero, V Linares… - Pharmaceutics, 2024 - mdpi.com
The production of tailored, on-demand drug delivery systems has gained attention in
pharmaceutical development over the last few years, thanks to the application of 3D printing …

Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D printing techniques

P Zhang, H Wang, S Chung, J Li, SK Vemula… - Journal of Drug Delivery …, 2024 - Elsevier
Abstract Three-dimensional (3D) printing is a potential technique for developing
personalized medicines. Among its applications, mold manufacturing in industrial 3D …