Research priorities towards precision antibiotic therapy to improve patient care
Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …
necessitates novel approaches to therapy. Over the past several decades, investigation of …
In vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam monotherapy with ceftazidime-avibactam-containing combination regimens against carbapenem …
Introduction Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant
Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity …
Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity …
Klebsiella Pneumoniae: An Update on Antibiotic Resistance Mechanisms
M Karami-Zarandi, HA Rahdar, H Esmaeili… - Future …, 2023 - Taylor & Francis
Klebsiella pneumoniae colonizes mucosal surfaces of healthy humans and is responsible
for one third of all Gram-negative infections in hospitalized patients. K. pneumoniae is …
for one third of all Gram-negative infections in hospitalized patients. K. pneumoniae is …
Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae
Background Aminoglycoside-containing regimens may be an effective treatment option for
infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but …
infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp), but …
Recent updates in treating carbapenem-resistant infections in patients with hematological malignancies
Introduction Patients with hematological malignancies (PHMs) are at increased risk for
infections caused by carbapenem-resistant organisms (CROs) due to frequent exposure to …
infections caused by carbapenem-resistant organisms (CROs) due to frequent exposure to …
Synergistic antibacterial activity of ceftazidime–avibactam in combination with colistin, gentamicin, amikacin, and fosfomycin against carbapenem-resistant Klebsiella …
Carbapenem-resistant Klebsiella pneumoniae (CPKP) infections seriously threaten global
public health. The main objective of this study was to assess the in-vitro synergistic activity of …
public health. The main objective of this study was to assess the in-vitro synergistic activity of …
A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials …
GM Assefa, JA Roberts, AT Aslan… - Journal of …, 2024 - academic.oup.com
Abstract Background Carbapenem-resistant Gram-negative bacteria (CR-GNB) develop
resistance to many antimicrobials. To effectively manage infections caused by these …
resistance to many antimicrobials. To effectively manage infections caused by these …
Critical role of growth medium for detecting drug interactions in Gram-negative bacteria that model in vivo responses
KP Davis, Y Morales, RJ Ende, R Peters, AL McCabe… - Mbio, 2024 - Am Soc Microbiol
The rise in infections caused by multidrug-resistant (MDR) bacteria has necessitated a
variety of clinical approaches, including the use of antibiotic combinations. Here, we tested …
variety of clinical approaches, including the use of antibiotic combinations. Here, we tested …
Interaction of Acinetobacter sp. RIT 592 induces the production of broad-spectrum antibiotics in Exiguobacterium sp. RIT 594
Antimicrobial resistance (AMR) is one of the most alarming global public health challenges
of the 21st century. Over 3 million antimicrobial-resistant infections occur in the United States …
of the 21st century. Over 3 million antimicrobial-resistant infections occur in the United States …
Prevalence and molecular characteristics of polymyxin-resistant Enterobacterales in a Chinese tertiary teaching hospital
Introduction Polymyxin-resistant Enterobacterales poses a significant threat to public health
globally, but its prevalence and genomic diversity within a sole hospital is less well known …
globally, but its prevalence and genomic diversity within a sole hospital is less well known …