Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

Immunotherapy has now been clinically validated as an effective treatment for many
cancers. There is tremendous potential for synergistic combinations of immunotherapy …

Cancer immunotherapies provide survival benefits in responding patients, but many patients
fail to respond. Identifying the biology of treatment response and resistance are a priority to …

Synthetic biology is a powerful tool to create therapeutics which can be rationally designed
to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli …

Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …

Purpose: Urelumab is an agonist antibody to CD137 with potential application as an
immuno-oncology therapeutic. Data were analyzed to assess safety, tolerability, and …

Melanoma is among the most sensitive of malignancies to immune modulation. Although
multiple trials conducted over decades with vaccines, cytokines, and cell therapies …

Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but
its efficacy has been variable across patients. Biomarkers to predict such differential …

Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer.
Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a …

During the past two decades, the paradigm for cancer treatment has evolved from relatively
nonspecific cytotoxic agents to selective, mechanism-based therapeutics. Cancer …