Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap
F Daneshnia, JN de Almeida Júnior, M Ilkit… - The Lancet …, 2023 - thelancet.com
Candida parapsilosis is one of the most commen causes of life-threatening candidaemia,
particularly in premature neonates, individuals with cancer of the haematopoietic system …
particularly in premature neonates, individuals with cancer of the haematopoietic system …
Recent advances in lipid metabolic engineering of oleaginous yeasts
A Chattopadhyay, M Mitra, MK Maiti - Biotechnology Advances, 2021 - Elsevier
With the increasing demand to develop a renewable and sustainable biolipid feedstock,
several species of non-conventional oleaginous yeasts are being explored. Apart from the …
several species of non-conventional oleaginous yeasts are being explored. Apart from the …
Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China
Candida parapsilosis is becoming a predominant non-albicans cause of invasive
candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis …
candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis …
[HTML][HTML] In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris
Objective Candida auris has emerged as a health-care-associated and multidrug-resistant
fungal pathogen of great clinical concern. As many as 50% of C. auris clinical isolates are …
fungal pathogen of great clinical concern. As many as 50% of C. auris clinical isolates are …
Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients …
F Daneshnia, JN de Almeida Júnior… - Emerging Microbes & …, 2022 - Taylor & Francis
Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal
infections such as COVID-19-associated candidemia (CAC), which are associated with poor …
infections such as COVID-19-associated candidemia (CAC), which are associated with poor …
The CRISPR toolbox in medical mycology: State of the art and perspectives
Fungal pathogens represent a major human threat affecting more than a billion people
worldwide. Invasive infections are on the rise, which is of considerable concern because …
worldwide. Invasive infections are on the rise, which is of considerable concern because …
Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples
CE O'Brien, J Oliveira-Pacheco, E Ó Cinnéide… - PLoS …, 2021 - journals.plos.org
Candida tropicalis is a human pathogen that primarily infects the immunocompromised.
Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in …
Whereas the genome of one isolate, C. tropicalis MYA-3404, was originally sequenced in …
Candida parapsilosis Mdr1B and Cdr1B are drivers of Mrr1-mediated clinical fluconazole resistance
Candida parapsilosis is a common cause of invasive candidiasis worldwide and is the most
commonly is7olated Candida species among pediatric and neonatal populations. Previous …
commonly is7olated Candida species among pediatric and neonatal populations. Previous …
[HTML][HTML] Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of …
Candida parapsilosis is a significant cause of candidemia worldwide. Echinocandin-
resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been …
resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been …
[HTML][HTML] Mutations in TAC1 and ERG11 are major drivers of triazole antifungal resistance in clinical isolates of Candida parapsilosis
LA Doorley, KS Barker, Q Zhang, JM Rybak… - Clinical Microbiology …, 2023 - Elsevier
Objectives The aim of this study was to determine how mutations in CpERG11 and CpTAC1
contribute to fluconazole resistance in a collection of clinical isolates. Methods Sequences of …
contribute to fluconazole resistance in a collection of clinical isolates. Methods Sequences of …