Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for
decades a “polar star” for studies on dementia and neurodegenerative diseases. Aim of the …

Background Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
neurotrophin 3 (NT-3), and neurotrophin 4/5 (NT-4/5) are members of the neurotrophin gene …

Nerve growth factor (NGF) is important for regulation, differentiation, and survival of
peripheral and central nervous system neurons, including basal forebrain cholinergic …

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been
identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase …

The biomedical literature on the subject of neurotrophic growth factors has expanded
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …

Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical
manifestations affecting the elderly. The pathologic and molecular substrate of people …

Neurotrophic factors (NTF) are small, versatile proteins that maintain survival and function to
specific neuronal populations. In general, the axonal transport of NTF is important as not all …