MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

AA Bhat, O Afzal, M Afzal, G Gupta, R Thapa… - … -Research and Practice, 2024 - Elsevier
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …

Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

MDSCs: key criminals of tumor pre-metastatic niche formation

Y Wang, Y Ding, N Guo, S Wang - Frontiers in immunology, 2019 - frontiersin.org
The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …

Myeloid-derived suppressor cells—new and exciting players in lung cancer

Z Yang, J Guo, L Weng, W Tang, S Jin… - Journal of hematology & …, 2020 - Springer
Lung cancer (LC) is the leading cause of cancer-related death worldwide due to its late
diagnosis and poor outcomes. As has been found for other types of tumors, there is …

LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis

Y Zhang, F Wang, G Chen, R He, L Yang - Cell & bioscience, 2019 - Springer
Background Many studies have reported that long noncoding RNAs (lncRNAs) could act as
sponges for microRNAs (miRNAs) and play important roles in the regulation of osteoarthritis …

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

Y Zhang, Q Mao, Q Xia, J Cheng, Z Huang, Y Li… - Journal of hematology & …, 2021 - Springer
Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Y Zhang, Q Liu, Q Liao - Journal of Experimental & Clinical Cancer …, 2020 - Springer
Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that
are highly linked to various cellular functions and pathological process. Emerging evidence …

LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis

S Wei, K Wang, X Huang, Z Zhao… - International journal of …, 2019 - journals.sagepub.com
This study was to investigate the expression correlation between long non-coding RNA
metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1), miR-200a-3p …

Immunotherapy targeting myeloid-derived suppressor cells (MDSCs) in tumor microenvironment

X Gao, H Sui, S Zhao, X Gao, Y Su, P Qu - Frontiers in immunology, 2021 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that accumulate in tumor-bearing hosts to reduce T cells activity and promote …

LncRNA-MALAT1: a key participant in the occurrence and development of cancer

L Hao, W Wu, Y Xu, Y Chen, C Meng, J Yun, X Wang - Molecules, 2023 - mdpi.com
LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides
and can interact with DNA, RNA, and proteins to regulate gene expression of malignant …