[HTML][HTML] Recent advances in chalcone-triazole hybrids as potential pharmacological agents
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …
compound by combining two or more pharmacophoric units. Being a linkage process, it …
A mini review on pharmacological significance of isatin-1, 2, 3-triazole hybrids
Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …
a novel hybrid molecule having better affinity and efficacy by combining two or more …
Synthesis, antimicrobial, antibiofilm and computational studies of isatin-semicarbazone tethered 1, 2, 3-triazoles
In present era, heterocyclic compounds containing two or three nitrogen atoms play a vital
role in drug discovery. In this context, a new class of isatin-semicarbazone tethered 1, 2, 3 …
role in drug discovery. In this context, a new class of isatin-semicarbazone tethered 1, 2, 3 …
Catalyst-free synthesis of imidazo [5, 1-b] quinazolines and their antimicrobial activity
PJ Patel, RM Vala, SG Patel, DB Upadhyay… - Journal of Molecular …, 2023 - Elsevier
Abstract In this study, imidazo [5, 1-b] quinazoline derivatives 4 (a–t) were synthesized via a
three-component reaction of 5-aminoimidazole-4-carbonitrile, 1, 3-cyclohexanedione …
three-component reaction of 5-aminoimidazole-4-carbonitrile, 1, 3-cyclohexanedione …
Synthesis of isatin-tagged thiadiazoles as anti-breast cancer leads: In-vitro and in-silico investigations
J Rasgania, R Gavadia, S Nimesh, L Loveleen… - Journal of Molecular …, 2023 - Elsevier
Despite rapid advances in drug accessibility for diagnosis and treatment, breast cancer
remains a common malignancy among women across the world due to the inadequacy of …
remains a common malignancy among women across the world due to the inadequacy of …
Isatin-semicarbazone linked acetamide 1, 2, 3-triazole hybrids: Synthesis, antimicrobial evaluation and docking simulations
N-Heterocycles stand out in medicinal chemistry as significant pharmacophores because of
their wide biological potential and structural diversity. In this perspective, we have …
their wide biological potential and structural diversity. In this perspective, we have …
Antimicrobial, antibiofilm, docking, DFT and molecular dynamics studies on click-derived isatin-thiosemicarbazone-1, 2, 3-triazoles
In an effort to develop new antimicrobial and antibiofilm agents, we have designed and
synthesized a novel class of isatin-thiosemicarbazone-1, 2, 3-triazoles through the CuAAC …
synthesized a novel class of isatin-thiosemicarbazone-1, 2, 3-triazoles through the CuAAC …
Glycerol based carbon sulfonic acid catalyzed synthesis, in silico studies and in vitro biological evaluation of isonicotinohydrazide derivatives as potent antimicrobial …
The present pathway involves synthesis of isonicotinohydrazide derivatives using isoniazid
and diversely substituted aldehydes in the presence of EtOH and catalytic amount of …
and diversely substituted aldehydes in the presence of EtOH and catalytic amount of …
Synthesis, X-ray crystallography, antimicrobial, molecular docking, and DFT study of bis-triazoles linked ampyrone
A new class of bis-triazoles linked with ampyrone molecules was synthesized from
ampyrone-linked bis-alkyne with different benzyl azides under Cu (I)-catalyzed azide-alkyne …
ampyrone-linked bis-alkyne with different benzyl azides under Cu (I)-catalyzed azide-alkyne …
Recent Advancement in Bioactive Chalcone Hybrids as Potential Antimicrobial Agents in Medicinal Chemistry
Chalcones are flavonoid-related aromatic ketones and enones generated from plants. The
chalcones have a wide range of biological activities, such as anti-tumor, calming, and …
chalcones have a wide range of biological activities, such as anti-tumor, calming, and …