Glutamatergic signaling in the central nervous system: ionotropic and metabotropic receptors in concert

A Reiner, J Levitz - Neuron, 2018 - cell.com
Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

Presynaptic calcium channels: specialized control of synaptic neurotransmitter release

AC Dolphin, A Lee - Nature Reviews Neuroscience, 2020 - nature.com
Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Heterogeneity of release probability, facilitation, and depletion at central synapses

LE Dobrunz, CF Stevens - Neuron, 1997 - cell.com
Previous studies of short-term plasticity in central nervous systems synapses have largely
focused on average synaptic properties. In this study, we use recordings from putative single …

Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus

R Shigemoto, A Kinoshita, E Wada… - Journal of …, 1997 - Soc Neuroscience
Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization of …

[HTML][HTML] Calcium channel regulation and presynaptic plasticity

WA Catterall, AP Few - Neuron, 2008 - cell.com
Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Glutamate receptors in the mammalian central nervous system

S Ozawa, H Kamiya, K Tsuzuki - Progress in neurobiology, 1998 - Elsevier
Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …

Salient features of synaptic organisation in the cerebral cortex

P Somogyi, G Tamas, R Lujan, EH Buhl - Brain research reviews, 1998 - Elsevier
The neuronal and synaptic organisation of the cerebral cortex appears exceedingly
complex, and the definition of a basic cortical circuit in terms of defined classes of cells and …

Overview of glutamatergic neurotransmission in the nervous system

MJ Niciu, B Kelmendi, G Sanacora - Pharmacology Biochemistry and …, 2012 - Elsevier
This introductory article to the special edition on glutamate neurotransmission in
neuropsychiatric disorders provides an overview of glutamate neurotransmitter system …

G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons

C Lüscher, LY Jan, M Stoffel, RC Malenka, RA Nicoll - Neuron, 1997 - cell.com
To study the role of G protein-coupled, inwardly rectifying K+(GIRK) channels in mediating
neurotransmitter actions in hippocampal neurons, we have examined slices from transgenic …

Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release

E Neher - Neuron, 1998 - cell.com
Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …