Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are
major regulators during mammary gland development, function and tumorigenesis …

The mammary gland undergoes a spectacular series of changes as it develops, and
maintains a remarkable capacity to remodel and regenerate for several decades. Mammary …

Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here …

The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …

The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and
involution to prepare the gland for subsequent lactation. The mammary epithelial cells …

Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast
growth, early dissemination, and rapid resistance to chemotherapy. We identified a …

Spheroidal cancer cell cultures have been used to enrich cancer stem cells (CSC), which
are thought to contribute to important clinical features of tumors. This study aimed to map the …

Estrogen and estrogen receptors (ERs) are critical regulators of breast epithelial cell
proliferation, differentiation, and apoptosis. Compromised signaling vis-à-vis the estrogen …

Remodeling of the extracellular matrix is beneficial during the acute wound healing stage
following tissue injury. In the short term, resident fibroblasts and myofibroblasts regulate the …

SnoN regulates multiple signaling pathways, including TGF-β/Smad and p53, and displays
both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed …