Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

Simple Summary Cancer stem cells (CSCs) in head and neck squamous cell carcinoma
(HNSCC) possess unlimited self-renewal capacity, resist treatments and induce tumor …

Background With the knowledge of tumor immunobiology deepening among researchers,
the breakthroughs in the field of tumor immunotherapy in recent years have provided new …

Simple Summary PD-L1 is an important immune checkpoint molecule that is expressed in
cancer tissues at various levels and plays a major role in tumor evasion from immune …

The continuing efforts to exploit the death receptor agonists, such as the tumour necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL), for cancer therapy, have largely …

Background Lung adenocarcinoma (LUAD) originates mainly from the mucous epithelium
and glandular epithelium of the bronchi. It is the most common pathologic subtype of non …

Investigating dietary polyphenolic compounds as antitumor agents are rising due to the
growing evidence of the close association between immunity and cancer. Cancer cells …

Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved
patient outcomes and offered new approaches to cancer therapy over the past decade. To …

Background Procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) are a group of
enzymes that can mediate the hydroxylation of lysyl to hydroxylysine and participate in the …