Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation
B Stieger - Drug transporters, 2011 - Springer
Bile formation is an important function of the liver. Bile salts are a major constituent of bile
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
The bile salt export pump (BSEP) in health and disease
R Kubitz, C Dröge, J Stindt, K Weissenberger… - Clinics and research in …, 2012 - Elsevier
The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from
hepatocytes into bile in humans. Mutations of BSEP are associated with cholestatic liver …
hepatocytes into bile in humans. Mutations of BSEP are associated with cholestatic liver …
Structure and function of hepatobiliary ATP binding cassette transporters
The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …
function requires an intensive crosstalk within liver cellular structures, but also with other …
[HTML][HTML] Membrane lipids and transporter function
B Stieger, J Steiger, KP Locher - … et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Transport proteins are essential for cells in allowing the exchange of substances between
cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids …
cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids …
Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11)
A comprehensive analysis was performed to investigate how inhibition of the human bile salt
export pump (BSEP/ABCB11) relates to clinically observed drug-induced liver injury (DILI) …
export pump (BSEP/ABCB11) relates to clinically observed drug-induced liver injury (DILI) …
Can bile salt export pump inhibition testing in drug discovery and development reduce liver injury risk? An international transporter consortium perspective
JG Kenna, KS Taskar, C Battista… - Clinical …, 2018 - Wiley Online Library
Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may
contribute to the initiation of human drug‐induced liver injury (DILI). Proactive evaluation …
contribute to the initiation of human drug‐induced liver injury (DILI). Proactive evaluation …
ABCC2/Abcc2: a multispecific transporter with dominant excretory functions
K Jemnitz, K Heredi-Szabo, J Janossy… - Drug metabolism …, 2010 - Taylor & Francis
ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the
canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of …
canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of …
An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters
Drug-induced cholestasis is an important form of acquired liver disease and is associated
with significant morbidity and mortality. Bile acids are key signaling molecules, but they can …
with significant morbidity and mortality. Bile acids are key signaling molecules, but they can …