Homozygous CYP2B6* 6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing …
K Tsuchiya, H Gatanaga, N Tachikawa, K Teruya… - Biochemical and …, 2004 - Elsevier
Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed
the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV …
the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV …
Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6* 6 and* 26
H Gatanaga, T Hayashida, K Tsuchiya… - Clinical infectious …, 2007 - academic.oup.com
Background. Efavirenz (EFV) is metabolized primarily by cytochrome P450 2B6 (CYP2B6),
and high plasma concentrations of the drug are associated with a G→ T polymorphism at …
and high plasma concentrations of the drug are associated with a G→ T polymorphism at …
Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography
G Aymard, M Legrand, N Trichereau… - Journal of Chromatography …, 2000 - Elsevier
A new high-performance liquid chromatography (HPLC) with UV detection assay was
developed for the simultaneous determination of protease inhibitors (PIs), nucleoside and …
developed for the simultaneous determination of protease inhibitors (PIs), nucleoside and …
Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor …
As part of an on-going study on the suitability of a formal therapeutic drug monitoring (TDM)
of antiviral drugs for improving the management of HIV infection, a high-performance liquid …
of antiviral drugs for improving the management of HIV infection, a high-performance liquid …
Simple and rapid liquid chromatography method for determination of efavirenz in plasma
G Ramachandran, AKH Kumar, S Swaminathan… - … of chromatography B, 2006 - Elsevier
A simple and rapid high performance liquid chromatographic method for determination of
efavirenz in human plasma was developed. The method involved extraction of sample with …
efavirenz in human plasma was developed. The method involved extraction of sample with …
Pharmacokinetics of efavirenz (EFV) alone and in combination therapy with nelfinavir (NFV) in HIV‐1 infected patients
Aims To define the pharmacokinetic profile of efavirenz (EFV) in HIV‐1 infected patients,
when administered alone or with nelfinavir (NFV). Methods Eleven HIV‐positive patients, in …
when administered alone or with nelfinavir (NFV). Methods Eleven HIV‐positive patients, in …
Simultaneous high-performance liquid chromatographic determination of the antiretroviral agents amprenavir, nelfinavir, ritonavir, saquinavir, delavirdine and …
V Proust, K Toth, A Hulin, AM Taburet… - … of Chromatography B …, 2000 - Elsevier
This article describes a method for the simultaneous determination of four licensed HIV
protease inhibitors (amprenavir, nelfinavir, saquinavir and ritonavir) and two novel non …
protease inhibitors (amprenavir, nelfinavir, saquinavir and ritonavir) and two novel non …
Determination of efavirenz in human plasma by high-performance liquid chromatography with ultraviolet detection
M Sarasa-Nacenta, Y López-Púa… - … of Chromatography B …, 2001 - Elsevier
Efavirenz is a non-nucleoside reverse transcriptase inhibitor for the treatment of the HIV
infection. A simple, high-performance liquid chromatographic method has been developed …
infection. A simple, high-performance liquid chromatographic method has been developed …
Determination of efavirenz, a selective non-nucleoside reverse transcriptase inhibitor, in human plasma using HPLC with post-column photochemical derivatization …
CZ Matthews, EJ Woolf, RS Mazenko… - … of pharmaceutical and …, 2002 - Elsevier
Methods for the quantitative determination of efavirenz in human plasma and the qualitative
assessment of the stereochemical integrity of efavirenz in post-dose human plasma samples …
assessment of the stereochemical integrity of efavirenz in post-dose human plasma samples …
High-performance liquid chromatographic method for the determination of HIV-1 non-nucleoside reverse transcriptase inhibitor efavirenz in plasma of patients during …
P Langmann, D Schirmer, T Väth, M Zilly… - … of Chromatography B …, 2001 - Elsevier
A new high-performance liquid chromatographic method for the determination of efavirenz in
human plasma is described. Quantitative recovery following liquid–liquid extraction with …
human plasma is described. Quantitative recovery following liquid–liquid extraction with …