Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation

SR Khan, BK Canales… - Nature Reviews …, 2021 - nature.com
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

[图书][B] An introduction to outlier analysis

CC Aggarwal, CC Aggarwal - 2017 - Springer
Outliers are also referred to as abnormalities, discordants, deviants, or anomalies in the data
mining and statistics literature. In most applications, the data is created by one or more …

A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

VH Canela, WS Bowen, RM Ferreira, F Syed… - Nature …, 2023 - nature.com
Kidney stone disease causes significant morbidity and increases health care utilization. In
this work, we decipher the cellular and molecular niche of the human renal papilla in …

Idiopathic hypercalciuria and formation of calcium renal stones

FL Coe, EM Worcester, AP Evan - Nature Reviews Nephrology, 2016 - nature.com
The most common presentation of nephrolithiasis is idiopathic calcium stones in patients
without systemic disease. Most stones are primarily composed of calcium oxalate and form …

An update on primary hyperoxaluria

B Hoppe - Nature Reviews Nephrology, 2012 - nature.com
The autosomal recessive inherited primary hyperoxalurias types I, II and III are caused by
defects in glyoxylate metabolism that lead to the endogenous overproduction of oxalate …

Current insights into the mechanisms and management of infection stones

EJ Espinosa-Ortiz, BH Eisner, D Lange… - Nature Reviews …, 2019 - nature.com
Infection stones are complex aggregates of crystals amalgamated in an organic matrix that
are strictly associated with urinary tract infections. The management of patients who form …

The interaction between Enterobacteriaceae and calcium oxalate deposits

E Barr-Beare, V Saxena, EE Hilt, K Thomas-White… - PloS one, 2015 - journals.plos.org
Background The role of calcium oxalate crystals and deposits in UTI pathogenesis has not
been established. The objectives of this study were to identify bacteria present in pediatric …

Mitochondrial dysfunction and kidney stone disease

S Chaiyarit, V Thongboonkerd - Frontiers in physiology, 2020 - frontiersin.org
Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of
energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone …

Urolithiasis unveiled: pathophysiology, stone dynamics, types, and inhibitory mechanisms: a review

EAH Allam - African Journal of Urology, 2024 - Springer
Urolithiasis is a multifaceted and common urological disorder characterized by the
development of renal calculi. Calcium oxalate stones are the most prevalent type of calculi …

The role of macromolecules in the formation of kidney stones

JD Rimer, AM Kolbach-Mandel, MD Ward, JA Wesson - Urolithiasis, 2017 - Springer
The formation of crystal aggregates, one of the critical processes in kidney stone
pathogenesis, involves interactions between crystals (predominantly calcium oxalate …