Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

High cholesterol is a major risk factor for cardiovascular disease. Currently, no drug lowers
cholesterol through directly promoting cholesterol excretion. Human genetic studies have …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

The mechanistic target of rapamycin (mTOR) pathway senses and integrates various
environmental and intracellular cues to regulate cell growth and proliferation. As a key …

Intracellular membrane protein trafficking is crucial for both normal cellular physiology and
cell-cell communication. The conventional secretory route follows transport from the …

The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino
acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often …