An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets

PIP Ramos, D Fernandez Do Porto, E Lanzarotti… - Scientific reports, 2018 - nature.com
Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can
cause life-threatening infections. It has been found as the culprit of many infection outbreaks …

Apicoplast metabolism: Parasite's Achilles' heel

K Kadian, Y Gupta, HV Singh… - Current topics in …, 2018 - ingentaconnect.com
Malaria continues to impinge heavily on mankind, with five continents still under its clasp.
Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current …

Integrating Omics Data to Prioritize Target Genes in Pathogenic Bacteria

MF Nicolás, M de Oliveira Cerqueira e Costa… - Networks in Systems …, 2020 - Springer
This review focuses on efforts toward target prioritization from several pathogenic bacteria
applying integrated multi-omics approaches. In an integrative scheme, diverse layers of …

Experiments of sexual selection and ploidy-specific effects of mutations in yeast

NLH Sandell - 2021 - open.library.ubc.ca
For organisms to genetically adapt, they need to have or acquire mutations that affect their
survival and reproductive success. The effects of mutations depend not only on the abiotic …

Genetic diversity and structural analysis of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) from Plasmodium falciparum

K Kadian, S Vijay, R Rawal, J Singh… - Journal of Vector …, 2018 - journals.lww.com
Methods: The study employed sequencing, modeling and bioinformatics approaches to
examine the genetic diversity and associated structural polymorphism in the PfIspE gene …

Genetic diversity and structural analysis of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) from Plasmodium falciparum.

KK Kavita Kadian, SV Sonam Vijay, RR Ritu Rawal… - 2018 - cabidigitallibrary.org
Background & objectives: Plasmodium parasite harbours unique methylerythritol phosphate
(MEP) pathway which is obligatory for the biosynthesis of isoprenoids. In malaria parasites …

[引用][C] Recent Insights Into Mechanism and Structure of MEP Pathway Enzymes and Implications for Inhibition Strategies

AA DeColli, ML Johnston, CLF Meyers - 2020 - Elsevier