Psoriasis is a common incurable inflammatory skin disease affecting 2–3% of the European
population. Psoriatic skin contains large numbers of immune cells which produce many …

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of
autoimmune nature that can be triggered or worsened by streptococcal throat infections. In …

Abstract α6β4 integrin and the Met receptor for HGF have been shown independently to
promote invasive growth. We demonstrate here that Met selectively associates with α6β4. In …

Background. Cell therapy is an emerging therapeutic strategy aimed at replacing or
repairing severely damaged tissues with cultured cells. Epidermal regeneration obtained …

Integrins α3β1 and α6β4 are abundant receptors on keratinocytes for laminin-5, a major
component of the basement membrane between the epidermis and the dermis in skin …

In the last few years, molecular genetics analyses have permitted novel insights into
psoriasis, a disease characterized by uncontrolled proliferation of keratinocytes and …

The molecular mechanism underlying the promotion of wound healing by TGF-beta 1 is
incompletely understood. We report that TGF-beta 1 regulates the regenerative/migratory …

We reported that interstitial collagenase is produced by keratinocytes at the edge of ulcers in
pyogenic granuloma, and in this report, we assessed if production of this metalloproteinase …

In injured skin, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is induced in migrating
keratinocytes. This site-specific expression is regulated by binding of the α 2 β 1 integrin with …

In 1991, a comprehensive review was published highlighting the importance of cytokines in
the immunopathogenesis of psoriasis. 1 Since then, many advances have been made re …