Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Mitochondria play an important role in numerous processes, including energy generation,
regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of …

The first draft human mitochondrial DNA (mtDNA) sequence was published in 1981, paving
the way for two decades of discovery linking mtDNA variation with human disease. Severe …

Several strands of evidence question the dogma that human mitochondrial DNA (mtDNA) is
inherited exclusively down the maternal line, most recently in three families where several …

Various pathogenic factors can lead to oogenesis failure and seriously affect both female
reproductive health and fertility. Genetic factors play an important role in folliculogenesis and …

The last decade has seen an increasingly large number of studies reporting on the
development of novel small organic conjugated systems for mitochondrial imaging …

Reactive oxygen species (ROS) is a term that defines a group of unstable compounds
derived from exogenous sources or endogenous metabolism. Under physiological …

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to
thousands copies in cells depending on cell metabolism and exposure to endogenous …