Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

The process of sexual differentiation is central for reproduction of almost all metazoan, and
therefore, for maintenance of practically all multicellular organisms. In sex development, we …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

As the mammalian embryo develops, it must engage one of the two distinct programmes of
gene activity, morphogenesis and organogenesis that characterize males and females. In …

There are numerous examples of sex differences in brain and behavior and in susceptibility
to a broad range of brain diseases. For example, gene expression is sexually dimorphic …

Functional differentiation of chromatin structure is essential for the control of gene
expression, nuclear architecture, and chromosome stability. Compelling evidence indicates …

Abstract X-linked ATR-X (alpha thalassemia, mental retardation, X-linked) syndrome in
males is characterized by mental retardation, facial dysmorphism, alpha thalassemia and …

Among the most defining events of an individual's life, is the development of a human
embryo into male or a female. The phenotypic sex of an individual depends on the type of …

Genome-wide epigenetic modification plays a pivotal role in regulating gene expression
through chromatin structure and stability, tissue-specific and embryonic developmental …

Disorders in human sex determination cause defects in gonadal function and can result in a
spectrum of abnormalities in the internal and external genitalia, ranging from relatively mild …