Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Motile growth cones lead growing axons through developing tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

Cell function depends on tissue rigidity, which cells probe by applying and transmitting
forces to their extracellular matrix, and then transducing them into biochemical signals. Here …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion,
links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the …

Directional cell migration requires force generation that relies on the coordinated
remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin …

Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions
(FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1 …

TCRs recognize peptides on MHC molecules and induce downstream signaling, leading to
activation and clonal expansion. In addition to the strength of the interaction of TCRs with …

Talin and vinculin are mechanosensitive proteins that are recruited early to integrin-based
nascent adhesions (NAs). In two epithelial cell systems with well-delineated NA formation …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …

Atherosclerosis is a leading cause of death worldwide as characterized by the accumulation
of lipid-overloaded macrophages exhibiting high expression of mannose receptors (MRs) in …