Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Multi-drug resistant pathogens have become a major threat to human health and new
antibiotics are urgently needed. Most antibiotics are derived from secondary metabolites …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Covering: 2011–July 2016 Myxobacteria are a rich source for structurally diverse secondary
metabolites with intriguing biological activities. Here we report on new natural products that …

Bacterial proteases are an extensive collection of enzymes that have vital roles in cell
viability, stress response and pathogenicity. Although their perturbation clearly offers the …

Myxobacteria are ubiquitous in soil environments. They display a complex life cycle:
vegetatively growing cells coordinate their motility to form multicellular swarms, which upon …

Bacteria possess a diverse range of mechanisms for inhibiting competitors, including
bacteriocins, tailocins, type VI secretion systems and contact-dependent inhibition (CDI) …

Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …