[HTML][HTML] Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers

J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …

FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation

S Zhou, ZL Bai, D Xia, ZJ Zhao, R Zhao… - Molecular …, 2018 - Wiley Online Library
The role of N6‐methyladenosine (m6A) demethylase fat mass and obesity‐associated
protein (FTO) in the regulation of chemo‐radiotherapy resistance remains largely unknown …

SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation

X Liu, J Liu, W Xiao, Q Zeng, H Bo, Y Zhu, L Gong… - …, 2020 - Wiley Online Library
Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy
rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered …

[HTML][HTML] FTO expression is associated with the occurrence of gastric cancer and prognosis

D Xu, W Shao, Y Jiang, X Wang, Y Liu… - Oncology …, 2017 - spandidos-publications.com
Fat mass and obesity associated (FTO) is a protein-coding gene. FTO gene is an obesity
related gene, also known as the obesity gene. It has been reported previously that FTO is …

The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels

K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …

[HTML][HTML] Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects

N Jiang, W Li, S Jiang, M Xie, R Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Protein acetylation modifications play a central and pivotal role in a myriad of biological
processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and …

FTO: a critical role in obesity and obesity-related diseases

D Yin, Y Li, X Liao, D Tian, Y Xu, C Zhou… - British Journal of …, 2023 - cambridge.org
In recent years, obesity is a growing pandemic in the world and has likely contributed to
increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene …

[HTML][HTML] Targeting FTO suppresses pancreatic carcinogenesis via regulating stem cell maintenance and EMT pathway

R Garg, L Melstrom, J Chen, C He, A Goel - Cancers, 2022 - mdpi.com
Simple Summary Current treatment strategies for pancreatic cancer (PC) yield poor survival
outcomes. It is thus essential to identify factors that orchestrate pancreatic tumorigenesis and …

Cell penetrating SERPINA5 (Protein C inhibitor, PCI): More questions than answers

H Yang, M Geiger - Seminars in Cell & Developmental Biology, 2017 - Elsevier
SERPINA5 (protein C inhibitor, plasminogen activator inhibitor-3) is a secreted, extracellular
clade A serpin. Its main characteristics are broad protease reactivity and wide tissue …