Malaria therapeutics: are we close enough?
Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …
Plasmodium. Malaria is a significant health problem and the leading cause of …
The metabolic advantage of tumor cells
M Israël, L Schwartz - Molecular cancer, 2011 - Springer
Oncogenes express proteins of" Tyrosine kinase receptor pathways", a receptor family
including insulin or IGF-Growth Hormone receptors. Other oncogenes alter the PP2A …
including insulin or IGF-Growth Hormone receptors. Other oncogenes alter the PP2A …
Antimalarial activity of small-molecule benzothiazole hydrazones
We synthesized a new series of conjugated hydrazones that were found to be active against
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
C Huthmacher, A Hoppe, S Bulik, HG Holzhütter - BMC systems biology, 2010 - Springer
Background Despite enormous efforts to combat malaria the disease still afflicts up to half a
billion people each year of which more than one million die. Currently no approved vaccine …
billion people each year of which more than one million die. Currently no approved vaccine …
[HTML][HTML] A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony
PK Sheokand, Y Yamaryo-Botté, M Narwal, CS Arnold… - Cell Reports, 2023 - cell.com
Phospholipid metabolism is crucial for membrane biogenesis and homeostasis of
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii
J Martin, G Crespo, V Gonzalez-Menendez… - Journal of natural …, 2014 - ACS Publications
Bioassay-guided fractionation of the crude fermentation extract of Heterospora chenopodii
led to the isolation of a novel monoacylglyceryltrimethylhomoserine (1). The structure of this …
led to the isolation of a novel monoacylglyceryltrimethylhomoserine (1). The structure of this …
Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system
Background New drugs are needed to treat visceral leishmaniasis (VL) because the current
therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We …
therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We …
Structure-based virtual screening approach reveals natural multi-target compounds for the development of antimalarial drugs to combat drug resistance
Compared to the previous year, there has been an increase of nearly 2 million malaria
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds
GJ Crowther, AJ Napuli, JH Gilligan, K Gagaring… - Molecular and …, 2011 - Elsevier
The efficacy of most marketed antimalarial drugs has been compromised by evolution of
parasite resistance, underscoring an urgent need to find new drugs with new mechanisms of …
parasite resistance, underscoring an urgent need to find new drugs with new mechanisms of …
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum
We have investigated the DNA-binding nature as well as the function of a putative Alba
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …