Intranasal liposomal formulation of spike protein adjuvanted with CpG protects and boosts heterologous immunity of hACE2 transgenic mice to SARS-CoV-2 infection

M Russo, MC Mendes-Corrêa, BB Lins, V Kersten… - Vaccines, 2023 - mdpi.com
Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this
study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a …

Saponin nanoparticle adjuvants incorporating Toll-like receptor agonists drive distinct immune signatures and potent vaccine responses

BS Ou, J Baillet, MV Filsinger Interrante… - Science …, 2024 - science.org
Over the past few decades, the development of potent and safe immune-activating adjuvant
technologies has become the heart of intensive research in the constant fight against highly …