Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …

Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …

Context For more precise, personalized care in prostate cancer (PC), a new classification
based on molecular features relevant for prognostication and treatment stratification is …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma
(GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due …

Over the last decade the unravelling of the molecular mechanisms of the DNA damage
response pathways and of the genomic landscape of human tumors have paved the road to …

Historically, cancers have been treated with chemotherapeutics aimed to have profound
effects on tumor cells with only limited effects on normal tissue. This approach was followed …

Synthetic lethality occurs when simultaneous perturbations of two genes or molecular
processes result in a loss of cell viability. The number of known synthetically lethal …