Water diffusion in brain tissue is affected by the presence of barriers to translational motion
such as cell membranes and myelin fibers. The measured water apparent diffusion …

Advances in neuroimaging have been central to the expansion of knowledge in the
neurosciences over the past 20 years. One of the most important roles of brain imaging is in …

Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in
animal models with delayed neuronal death via a number of indirect bystander effects. A …

Background and Purpose—With the advent of thrombolytic therapy for acute stroke,
reperfusion-associated mechanisms of tissue injury have assumed greater importance. In …

During ischemic stroke, neurons at risk are exposed to pathologically high levels of
intracellular calcium (Ca++), initiating a fatal biochemical cascade. To protect these neurons …

Background and Purpose—The early ischemic lesions demonstrated by diffusion-weighted
imaging (DWI) are potentially reversible. The purposes of this study were to determine …

This study was designed to determine whether formalin fixation alters diffusion parameters
in the infarcted brain. Diffusion tensor images were obtained from anesthetized mice 1 hr …

Purpose: To examine whether the severity and spatial distribution of reductions in apparent
diffusion coefficient (ADC) are associated with clinical outcomes in patients who become …

Although animal models have demonstrated that late secondary cerebral injury after arterial
occlusion and subsequent recanalization may limit the benefit of reperfusion therapy, this …

Stroke is the most common cause of adult disability in developed countries, largely because
spontaneous recovery is often incomplete, and no pharmacological means to hasten the …