Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While
complete remission can be obtained with intensive chemotherapy in young and fit patients …

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) …

Abstract Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically
heterogeneous set of diseases, which are characterised by an increased growth of …

Despite the advances in intensive chemotherapy regimens and targeted therapies, overall
survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable …

Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …

Accumulating evidence suggests that the clinical efficacy of selected anticancer drugs,
including conventional chemotherapeutics as well as targeted anticancer agents, originates …

Venous thromboembolism is a common complication in patients with cancer, but only limited
data are available in acute myeloid leukemia (AML). In a prospective study in a cohort of 272 …

The long-established notion that apoptosis would be immunologically silent, and hence it
would go unnoticed by the immune system, if not tolerogenic, and hence it would actively …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …