Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology

YO Ayipo, I Ahmad, CF Chong… - Journal of …, 2024 - Taylor & Francis
The human serotonin transporters (hSERTs) are neurotransmitter sodium symporters of the
aminergic G protein-coupled receptors, regulating the synaptic serotonin and …

Blockage of the monoamine oxidase by a natural compound to overcome parkinson's disease via computational biology

M Sherafatizangeneh, C Farshadfar… - Journal of …, 2022 - World Scientific
The dopamine (DA) metabolism changes are significant in Parkinson's disease (PD). Levels
of monoamine oxidases (MAOs) play a critical role in DA metabolism and oxidative damage …

Classification of cancer cells and gene selection based on microarray data using MOPSO algorithm

MR Rahimi, D Makarem, S Sarspy, SA Mahdavi… - Journal of Cancer …, 2023 - Springer
Purpose Microarray information is crucial for the identification and categorisation of
malignant tissues. The very limited sample size in the microarray has always been a …

Computational-driven discovery of AI-2 quorum sensing inhibitor targeting the 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) to combat …

M Kumar, AK Ashok, T Bhat, K Ballamoole… - Computers in Biology …, 2025 - Elsevier
MTAN is an attainable therapeutic target for H. pylori because it may minimize virulence
production, limit resistance, and impair quorum sensing without affecting gut flora. Here, 457 …

Facilitation of infectious and non-infectious wound healing using Morus nigra fruit extract ointment: An in vitro and in vivo study

F Sharifee, L Asadpour, S Shariati… - International …, 2024 - Elsevier
Accelerating wound healing, as well as preventing infection and scar formation are among
the most important medical challenges. This study aims to examine the antimicrobial …

Early Blockage of Mycobacterium Tuberculosis Cell-wall Synthesis via EchA\6 Inhibition to Overcome Resistance Strain: Insights from Umbrella Sampling Simulations

RH Askandar, F Sharifi, S Shayan… - Current Bioactive …, 2023 - ingentaconnect.com
Background: Tuberculosis (TB) has long been the major infectious cause of mortality,
ranking higher than HIV/AIDS as the most common cause of death from a single infectious …

Investigation of production mechanism, structure, and formulation of Se-methyl methaneselenoate and its halogen derivatives by density functional theory (DFT)

FF Irsafli, L Mahdavian, A Marjani - Computational and Theoretical …, 2023 - Elsevier
In this study, the production mechanism of Se-methyl methaneselenoate in the presence of
carbon monoxide against copper oxide nanoparticles simulation and investigated its most …

[PDF][PDF] Identification and Characterization of Indolebutyroyl Aspartic Acid: A Promising Inhibitor of VIM-2 Metallo-β-Lactamase Against Carbapenem-Resistant …

SS Moosavi, M Madani, S Mirzaie, NH Jazani - 2023 - brieflands.com
Abstract Background: β-lactamases (BLs) are the leading cause of antimicrobial resistance
in gram-negative bacteria. Metallo-β-lactamases (MBL) play a critical role in hydrolyzing a …

[HTML][HTML] Discovery of a Potent Inhibitor to Overcome Carbapenem Resistance in Pseudomonas aeruginosa Strains via Inhibition of VIM-2 Metallo-β-lactamases

SS Moosavi, M Madani, S Mirzaie… - Journal of Health Reports …, 2022 - brieflands.com
Background: Mutations in bacteria frequently occur that display a crucial need for new
antimicrobial agents. Metallo-β-lactamases (MBLs) are a growing threat to maintaining the …

Evaluating the Cavitary Lung Lesions on CT Scan of COVID-19 Patients: A Retrospective Study

G Moradi, SS Etehadi… - Journal of …, 2024 - scholarlycommons.gbmc.org
Background: It has been shown that cavitary lesions on CT scans of patients with COVID-19
may be related to their clinical symptoms and mortality rate. Materials and methods: The …