Aquaporins and cell migration

MC Papadopoulos, S Saadoun… - Pflügers Archiv-European …, 2008 - Springer
Aquaporin (AQP) water channels are expressed primarily in cell plasma membranes. In this
paper, we review recent evidence that AQPs facilitate cell migration. AQP-dependent cell …

The adult human brain in preclinical drug development

M Dragunow - Nature reviews Drug discovery, 2008 - nature.com
Neurodegenerative disorders are caused by the death and dysfunction of brain cells, but
despite a huge worldwide effort, no neuroprotective treatments that slow cell death currently …

Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c‐Jun/AP‐1 pathway and switch on GFAP expression

K Gao, CR Wang, F Jiang, AYK Wong, N Su, JH Jiang… - Glia, 2013 - Wiley Online Library
Astrocyte activation is a hallmark of central nervous system injuries resulting in glial scar
formation (astrogliosis). The activation of astrocytes involves metabolic and morphological …

[HTML][HTML] Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology

J Leach, AKH Achyuta, SK Murthy - Frontiers in neuroengineering, 2010 - frontiersin.org
Neuroprosthetic devices have made a major impact in the treatment of a variety of disorders
such as paralysis and stroke. However, a major impediment in the advancement of this …

β− Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR‐α, PPAR‐γ and TRPV1, but not CB1 or …

C Benito, RM Tolón, AI Castillo… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE The endocannabinoid system may regulate glial cell
functions and their responses to pathological stimuli, specifically, Alzheimer's disease. One …

[HTML][HTML] Exposure to inflammatory cytokines IL-1β and TNFα induces compromise and death of astrocytes; implications for chronic neuroinflammation

C van Kralingen, DT Kho, J Costa, CE Angel… - PloS one, 2013 - journals.plos.org
Background Astrocytes have critical roles in the human CNS in health and disease. They
provide trophic support to neurons and are innate-immune cells with keys roles during states …

[HTML][HTML] From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia

JY Park, JJ Park, S Jeon, AR Doo, SN Kim, H Lee… - The Journal of …, 2014 - Elsevier
Despite accumulating evidence of the clinical effectiveness of acupuncture, its mechanism
remains largely unclear. We assume that molecular signaling around the acupuncture …

High-content analysis in neuroscience

M Dragunow - Nature Reviews Neuroscience, 2008 - nature.com
High-content analysis (HCA) combines automated microscopy and automated image
analysis to quantify complex cellular anatomy and biochemistry objectively, accurately and …

Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology

K Moodley, CE Angel, M Glass, ES Graham - Journal of neuroscience …, 2011 - Elsevier
We have conducted the first profiling of human Natural Killer (NK) cell mediated killing of
astrocytes using xCELLigence technology. The sensitivity and applicability of xCELLigence …

MAPK induces AQP1 expression in astrocytes following injury

E Mccoy, H Sontheimer - Glia, 2010 - Wiley Online Library
Abstract Aquaporin‐4 (AQP4) is the principle water channel and the primary route for water
transport across astrocytic membranes. AQP4 co‐localizes with Kir4. 1 channels at astrocytic …