Bacterial persister cells constitute a subpopulation of genetically identical, metabolically
slow-growing cells that are highly tolerant of antibiotics and other environmental stresses …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …

Progression through the cell cycle is controlled by regulated and abrupt changes in
phosphorylation. Mitotic entry is initiated by increased phosphorylation of mitotic proteins, a …

The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress
response of all eukaryotic cells. The growth-arrest-and DNA-damage-induced transcript 34 …

SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS
cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is …

The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human
cancers,–. However, our mechanistic understanding of how RAS signals through RAF is still …

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S
phase transition and plays critical roles in tumour suppression. It is frequently inactivated in …