The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …

Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

The inducible nitric oxide signaling (iNOS) pathway is associated with poor prognosis in
triple-negative breast cancer (TNBC). Prior studies using in vivo models showed that …

Macrophages are key participants in melanoma growth and survival. In general,
macrophages can be classified as M1 or M2 activation phenotypes. Increasing evidence …

Fluorouracil (5‐FU) is one of the most commonly used chemotherapeutic agents in colon
cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …