Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and
development, but also sensitizes the function of various immune cells in the immune …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as
ligand-dependent transcription factors that can be activated by different types of fatty acids …

The mango fruit is of great economic value worldwide and of great nutritional importance. Its
functional effects are due to numerous important nutrients and bioactive compounds. In this …

Background: Peroxisome proliferator-activated receptors (PPARs) have demonstrated a lot
of important effects in the regulation of glucose and lipid metabolism and in the correct …

In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …

Zinc is one of the essential trace elements and participates in numerous physiological
processes. Abnormalities in zinc homeostasis often result in the pathogenesis of various …

Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic
function, which leaves the heart unable to pump enough blood to meet the normal …

Cardiomyocytes mainly depend on energy produced from the oxidation of fatty acids and
mitochondrial oxidative phosphorylation. Shortage of energy or excessive fat accumulation …

Polychlorinated biphenyls (PCBs) are a typical class of environmental contaminants recently
shown to be metabolism-disrupting chemicals. Lipids are a highly complex group of …