Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …

Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to
study the causal effect of exposure on outcome using summary statistics from genome-wide …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

DNA damage occurs throughout tumorigenesis and development. The immunogenicity of
DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses …

Abstract Cyclic GMP‐AMP synthase (cGAS) functions as a key sensor for microbial invasion
and cellular damage by detecting emerging cytosolic DNA. Here, we report that GTPase …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

Aberrant glucose metabolism and elevated O-linked β-N-acetylglucosamine modification (O-
GlcNAcylation) are hallmarks of hepatocellular carcinoma (HCC). Loss of …