Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Mitophagy in Parkinson's disease: from pathogenesis to treatment

J Liu, W Liu, R Li, H Yang - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …

Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated …

Q Zhang, C Zhang, J Ge, MW Lv, M Talukder, K Guo… - Food & function, 2020 - pubs.rsc.org
Cadmium (Cd) is a toxic pollutant with high nephrotoxicity in the agricultural environment.
Resveratrol has been found to have a renoprotective effect but the underlying mechanisms …

The role of mitophagy in innate immune responses triggered by mitochondrial stress

Y Song, Y Zhou, X Zhou - Cell Communication and signaling, 2020 - Springer
Mitochondria are important cellular organelles involved in many different functions, from
energy generation and fatty acid oxidation to cell death regulation and immune responses …

Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

V Manganelli, P Matarrese, M Antonioli… - Autophagy, 2021 - Taylor & Francis
Mitochondria-associated membranes (MAMs) are essential communication subdomains of
the endoplasmic reticulum (ER) that interact with mitochondria. We previously demonstrated …

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

G López‐Doménech, JH Howden… - The EMBO …, 2021 - embopress.org
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …

Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

VL Hewitt, L Miller-Fleming, MJ Twyning… - Life Science …, 2022 - life-science-alliance.org
Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions
including regulating mitochondrial quality control through mitophagy and mediating …

Mitophagy, a form of selective autophagy, plays an essential role in mitochondrial dynamics of parkinson's disease

XL Wang, ST Feng, YT Wang, YH Yuan, ZP Li… - Cellular and molecular …, 2022 - Springer
Parkinson's disease (PD) is a severe neurodegenerative disorder caused by the progressive
loss of dopaminergic neurons in the substantia nigra and affects millions of people …

Mitochondrial quality control: a pathophysiological mechanism and therapeutic target for stroke

M Yang, Y He, S Deng, L Xiao, M Tian, Y Xin… - Frontiers in Molecular …, 2022 - frontiersin.org
Stroke is a devastating disease with high mortality and disability rates. Previous research
has established that mitochondria, as major regulators, are both influenced by stroke, and …

Mitochondrial redox-driven mitofusin 2 S-glutathionylation promotes neuronal necroptosis via disrupting ER-mitochondria crosstalk in cadmium-induced neurotoxicity

L Che, CL Yang, Y Chen, ZL Wu, ZB Du, JS Wu… - Chemosphere, 2021 - Elsevier
Reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and
mitochondrial dysfunction are known to affect the structural and functional damage in the …