The study of medications among pediatric patients has increased worldwide since 1997 in
response to new legislation and regulations, but these studies have not yet adequately …

Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …

The saemix package for R provides maximum likelihood estimates of parameters in
nonlinear mixed effect models, using a modern and efficient estimation algorithm, the …

Background Childhood obesity is a major public health concern with limited treatment
options. Objective The aim of this study was to assess safety, tolerability, pharmacokinetics …

Charting human brain maturation between childhood and adulthood is a fundamental
prerequisite for understanding the rapid biological and psychological changes during …

Several developments have facilitated the practical application and increased the general
use of optimal design for nonlinear mixed effects models. These developments include new …

Nonlinear mixed effect models (NLMEM) with multiple responses are increasingly used in
pharmacometrics, one of the main examples being the joint analysis of the pharmacokinetics …

Population pharmacokinetic (PK)–pharmacodynamic (PKPD) models are increasingly used
in drug development and in academic research; hence, designing efficient studies is an …

Abstract Background and Objective Nonlinear mixed-effect models (NLMEMs) are
increasingly used for the analysis of longitudinal studies during drug development. When …

Efficient power calculation methods have previously been suggested for Wald test-based
inference in mixed-effects models but the only available alternative for Likelihood ratio test …